1. **Severe Lethargy**: If your puppy seems excessively tired or unresponsive compared to their normal behavior, it’s worth checking in with your vet.
2. **Persistent Vomiting or Diarrhea**: Occasional mild gastrointestinal upset can occur, but if your puppy has ongoing vomiting or diarrhea, especially if it’s severe, contact your vet.
3. **Swelling or Pain at the Injection Site**: A small lump or mild soreness can be normal, but if you notice significant swelling, heat, or pain, you should reach out to your vet.
4. **Loss of Appetite**: If your puppy refuses to eat for more than 24 hours post-vaccination, it’s advisable to consult your vet.
5. **Difficulty Breathing or Swelling**: Any signs of an allergic reaction, such as difficulty breathing, swelling of the face or throat, or hives, require immediate veterinary attention.
6. **Fever**: A mild fever can be normal, but if your puppy's temperature exceeds 103°F (39.4°C), contact your vet for advice.
Remember, while some mild reactions are common after vaccinations, it’s always better to err on the side of caution and consult your veterinarian if you have any concerns about your puppy's health post-vaccination.
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