Yes, it is completely normal for puppies to feel tired after receiving vaccinations. Vaccines work by stimulating the puppy's immune system to build protection against certain diseases, which can lead to temporary fatigue. After vaccination, your puppy might also experience mild side effects such as slight fever, decreased appetite, or soreness at the injection site. These symptoms usually resolve within a day or two. To help your puppy feel more comfortable, ensure they have a calm and quiet space to rest, provide fresh water, and monitor them for any unusual behavior. If tiredness persists beyond 24 hours or if you notice severe reactions, it's best to consult your veterinarian.

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Topics covered in this question:

Dog Behavior Puppy Care Puppy Health Vaccination Veterinary Advice