There are several signs to look out for to determine if your puppy is sick. These include changes in appetite, lethargy, vomiting, diarrhea, coughing, sneezing, nasal discharge, excessive scratching or licking, difficulty breathing, and changes in behavior such as increased aggression or fearfulness. If you notice any of these signs, it's important to consult your veterinarian for a proper diagnosis and treatment.

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Topics covered in this question:

Puppy Care Puppy Behavior Puppy Health Dog Illness